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Nutsche filters & filter-dryers pharma

Nutsche Filters & Filter-Dryers Pharma

Pressofiltro® Series PF 100 - PF 6000 Pharmaceutical design

COMBER Pressofiltro® nutsche filters or filter dryers are versatile units designed for multipurpose production facilities. To meet the demanding requirements for filters used in the manufacture of pharmaceutical ingredients, the filters are designed to meet stringent cGMP and FDA guidelines.

Excellent cleanability using CIP systems, simple validation. An openable filter base provides for good access to the filter internals for cleaning and inspection. Easily interchangeable filter plates, with flat, homogeneous filter surfaces for good cleanability and inspection.
Multilayer and/or conventional filter materials.

Good drying performance with special agitator design, large heat exchange areas. Suitable for supplemental microwave heating.

 

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Inerting

Prior to feeding slurry into the agitated Nutsche filter or filter dryer the vessel interior is inerted by a controlled displacement of the oxygen containing atmosphere with Nitrogen. This procedure prevents the potential formation of an explosive atmosphere in the vessel interior.

Filling

Afbeelding: pf100-6000 filling

After inertization is completed the slurry is fed into the vessel.

Filtration

filtration

The slurry is filtered by pressurizing the vessel interior using Nitrogen and/or evacuating the area underneath the filter plate. Solids are retained by the filter cloth whereas the mother liquor passes thru the filter cake forming and thru the filter cloth and is discharged from the area underneath the filter plate.

Washing

Afbeelding: pf100-6000 washing

Once the mother liquor has been filtered off the cake washing step is initiated. 

Prior to displacement washing the filter cake surface is smoothed using the agitator to prevent cracks in the filter cake.

The washing liquid is evenly distributed over the entire filter cake surface using a wash ring with spray nozzles. By again pressurizing the vessel interior the washing liquid is forced thru the filter cake, displacing any remaining mother liquor and is discharged the same way as the mother liquor during the filtration.


In the reslurry washing process the washing liquid is added to the vessel and mixed with the filter cake using the agitator. By again pressurizing the vessel interior the washing liquid is forced thru the filter cake, displacing any remaining mother liquor and is discharged the same way as the mother liquor during the filtration.

Drying

Afbeelding: pf100-6000 drying

After completion of the washing process the drying process is initiated. For efficient drying the filter dryer is typically evacuated in steps and heated up at the same time. During the drying process the product is agitated. The filter dryer is maintained under vacuum and at the maximum allowable temperature for the product until the final required product humidity level is reached.

Cooling

Afbeelding: pf100-6000 cooling

After drying is completed the product is cooled down prior to discharging.

Discharging

Afbeelding: pf100-6000 discharging

The dried and cooled product is discharged thru the side discharge valve. The product is transported to the discharge valve using the agitator.

Cleaning

Afbeelding: pf100-6000 cleaning

Using spray balls a cleaning fluid is sprayed onto all product wetted internal surfaces for the internal cleaning of the equipment in between individual batches or for product change over. This provides for full and efficient cleaning of the filter dryer interior.

Technical data

Special properties for the customer’s benefit:

  • calculation, design and manufacture in compliance with Pressure Equipment Directive 97/23/EG or/and ASME pressure vessel code, Section VIII, with U-stamp as well as with cGMP and FDA guidelines
  • EG type examination certification 03ATEX0246X in accord with PED 94/9/EG or with UL-approved electrical components for operations in class 1, division 1 or 2, group C & D surroundings
  • double mechanical seal, externally interchangeable, dry running contact or non contacting gas-lubricated seal (lift-off), as well as liquid-lubricated seals
  • sampler valve
  • hydraulic pre-piping made of stainless steal, pre-wiring on terminal box made of stainless steal
  • excellent cleanability using CIP-systems, simple validation


Options

  • additional heating with microwaves to reduce the drying process
  • sterile versions, removal of the residual layer, isolators (glove box), DQ, IQ, OQ qualification
  • autonomic PLC control or connected to PMSX

Technical data

Dryer
type
 		 Internal
Ø
mm		 Filter area
m²
 		 Nominal volume
l
 		 Cake volume
max.
l		 Speed
max.
1/min		 Drive
kw
PF 100 500 0.20 100 32 50 4.0
PF 200 640 0.32 230 80 74 4.0
PF 250 700 0.38 280 115 70 5.5
PF 350 800 0.50 400 150 60 5.5
PF 500 S 875 0.60 500 180 52 7.5
PF 500 955 0.70 640 210 46 7.5
PF 750 1050 0.85 770 340 40 7.5
PF 1000 S 1150 1.00 930 415 40 11.0
PF 1000 1270 1.26 1140 505 37 11.0
PF 1500 1380 1.50 1500 750 30 15.0
PF 2000 1600 2.00 2000 1000 30 18.5
PF 2500 1800 2.50 2500 1250 25 18.5
PF 3000 1960 3.00 3000 1500 25 22
PF 4000 2260 4.00 4000 2000 21 22
PF 5000 2535 5.00 5000 2500 18 30
PF 6000 2765 6.00 6000 3000 17 30
 

 

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Fields of application
Pharmaceutical
Pharmaceutical